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MDPI AG

The Potential Role of sPD-L1 as a Predictive Biomarker in EGFR-Positive Non-Small-Cell Lung Cancer

Background/Objectives: A significant breakthrough in non-small-cell lung cancer (NSCLC) treatment has occurred with the introduction of targeted therapies and immunotherapy. However, not all patients treated with these therapies would respond to treatment, and patients who respond to treatment would acquire resistance at some time point. This is why we need new biomarkers that can predict response to therapy. The aim of this study was to investigate whether soluble programmed cell death-ligand 1...

Preuzmite dokument 2025 Ivan Soldatović , Damir Radončić , Biljana Šeha , Dragana Jovanović , Milan Savić , Natalija Samardžić , Aleksandra Klisic , Jelena Kotur Stevuljević , Milija Gajić , Marina Roksandić Milenković , ... Pogledajte sve

MDPI AG

Expression Analysis of Circulating miR-21, miR-34a and miR-122 and Redox Status Markers in Metabolic Dysfunction-Associated Steatotic Liver Disease Patients with and Without Type 2 Diabetes

Metabolic dysfunction-associated steatotic liver disease (MASLD), a hepatic form of metabolic syndrome, often co-occurs with type 2 diabetes (T2D) and now affects approximately 30% of the global population. MASLD encompasses conditions from simple steatosis to metabolic dysfunction-associated steatohepatitis, with oxidative stress (OS) driving progression through inflammation. This study analyzes the expression levels of circulating miRNAs and redox status markers in MASLD patients with and without...

Preuzmite dokument 2025 Sanja Erceg , Sanja Vujcic , Miron Sopić , Miloš Mitrović , Jelena Kotur-Stevuljevic , Aleksandra Klisic , Milica Mamić , Ana Ninic , Jelena Munjas , Ratko Tomašević

Bentham Science Publishers Ltd.

Therapeutic Potential of Sodium-glucose Co-transporter-2 Inhibitors and Glucagon-like Peptide-1 Receptor Agonists for Patients with Acute Coronary Syndrome: A Review of Clinical Evidence

: Atherosclerotic Cardiovascular Disease (ASCVD) is still one of the leading causes of death globally, with Coronary Artery Disease (CAD) being the most prevalent form of ASCVD. Patients with type 2 Diabetes Mellitus (DM) experience an increased risk for ASCVD during the disease course, with CAD being the most common cause of death among affected individuals, resulting in shorter life expectancy and increased morbidity among survivors. Recently, 2 novel classes of anti-diabetic drugs, namely Sodium-Glucose...

Preuzmite dokument 2024 Paschalis Karakasis , Manfredi Rizzo , Nikolaos Fragakis , Theocharis Koufakis , Michael Doumas , Aleksandra Klisic , Dimitrios Patoulias , George Kassimis

Wiley

Effects of glucagon‐like peptide‐1 receptor agonists on glycated haemoglobin and continuous glucose monitoring metrics as adjunctive therapy to insulin in adults with type 1 diabetes: A meta‐analysis of randomized controlled trials

AbstractAimsTo conduct a meta‐analysis of randomized controlled trials (RCTs) to evaluate the effect of glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) on glycated haemoglobin (HbA1c) and continuous glucose monitoring (CGM) metrics as an adjunct to insulin therapy in adults with type 1 diabetes mellitus (T1D).MethodsA systematic literature search was conducted through Medline (via PubMed), Cochrane Library, and Google Scholar up to 27 May 2024. Dual‐independent study selection, data extraction,...

Preuzmite dokument 2024 Paschalis Karakasis , Fotios Barkas , Theocharis Koufakis , Michael Doumas , Nikolaos Papanas , Aleksandra Klisic , Djordje S. Popovic , Milena Mitrovic , Dimitrios Patoulias

Mary Ann Liebert Inc

Are Oxidative Stress Biomarkers Reliable Part of Multimarker Panel in Female Patients with Type 2 Diabetes Mellitus?

Preuzmite dokument 2024 Paschalis Karakasis , Amirmohammad Khalaji , Aleksandra Klisic , Ana Ninic , Dimitrios Patoulias

MDPI AG

Investigating the Hepatic Response to Orlistat and White Tea in Rats on a High-Fat Diet

High-fat diets have detrimental health impacts that increase the likelihood of developing obesity and metabolic syndrome. This study aimed to examine the potential antioxidant and anti-inflammatory effects of orlistat and white tea in rats fed a high-fat diet. Thirty-two rats were randomized into four groups: control (standard diet), HFD (high-fat diet), HFD+Orlistat (high-fat diet+orlistat), and HFD+WT (high-fat diet+white tea extract). A significant increase in malondialdehyde (MDA) levels and...

Preuzmite dokument 2024 Adnan Yilmaz , Merve Nur Toraman , Filiz Mercantepe , Sedat Ciftel , Esra Pinarbas , Enver Ciftel , Aleksandra Klisic , Serpil Ciftel , Tolga Mercantepe

MDPI AG

Cardiovascular Risk in Patients with Ankylosing Spondylitis

Objectives: Ankylosing spondylitis (AS) is an autoinflammatory, chronic disease. Patients with AS are at increased risk of cardiovascular disease (CVD). The link between AS and subclinical atherosclerosis is multifactorial and still not completely understood. The aim of this study was to examine the potential associations between carotid intima–media thickness (cIMT) and different cardiometabolic biomarkers in individuals with AS. Methods: A total of 96 patients with AS were prospectively included....

Preuzmite dokument 2024 Filiz Mercantepe , Osman Cure , Bayram Kizilkaya , Jelena Kotur-Stevuljevic , Aleksandra Klisic , Fatma Beyazal Celiker , Huseyin Er

MDPI AG

New Approaches Based on Inflammatory Indexes in the Evaluation of the Neoplastic Potential of Colon Polyps

Colorectal polyps, precursors to colorectal cancer (CRC), require precise identification for appropriate diagnosis and therapy. This study aims to investigate the differences in hematological and inflammatory markers, specifically the CALLY index, HALP score, and immuno-inflammatory indexes, between neoplastic and nonneoplastic polyps. A retrospective cross-sectional study was conducted on 758 patients aged 61.0 ± 11.8 who underwent polypectomy between June 2021 and May 2024. Patients with colorectal...

Preuzmite dokument 2024 Filiz Mercantepe , Sedat Ciftel , Aleksandra Klisic , Serpil Ciftel

MDPI AG

Sex-Specific Associations between Thyroid Status, Inflammation and Hemostasis Biomarkers in Patients with Subacute Thyroiditis

Background: Subacute thyroiditis (SAT) is characterized by profound inflammation and fluctuations in thyroid hormones which may affect the hemostasis balance. This study investigates sex-specific associations between thyroid status, inflammation and hemostasis biomarkers in SAT. Methods: We included 52 patients (40 women and 12 men) treated with non-steroidal anti-inflammatory drugs (NSAID) or methylprednisolone (MPS). Free thyroxine (fT4), thyroid stimulating hormone, C-reactive protein, complete...

Preuzmite dokument 2024 Filiz Mercantepe , Jelena Vekic , Neda Milinkovic , Sanja Gluscevic , Jelena Kotur-Stevuljevic , Aleksandra Klisic , Serpil Ciftel

MDPI AG

Cardiometabolic Risk Factors Related to Atrial Fibrillation and Metabolic Syndrome in the Pakistani Population

Background and Objectives: This study aimed to examine the relationship between cardiometabolic risk factors and atrial fibrillation (AF) and the simultaneous presence of AF and metabolic syndrome (MetS) in the Pakistani population. Materials and Methods: A total of 690 subjects were enrolled (n = 230 patients with AF, n = 230 patients with AF and MetS, and n = 230 controls). The associations between cardiometabolic parameters and AF with and without MetS were analyzed by univariable and multivariable...

Preuzmite dokument 2024 Saima Sharif , Shagufta Naz , Filiz Mercantepe , Sanja Gluscevic , Saira Rafaqat , Aleksandra Klisic , Ana Ninic