Digital platoform

MDPI AG

Sex-Specific Associations between Thyroid Status, Inflammation and Hemostasis Biomarkers in Patients with Subacute Thyroiditis

Background: Subacute thyroiditis (SAT) is characterized by profound inflammation and fluctuations in thyroid hormones which may affect the hemostasis balance. This study investigates sex-specific associations between thyroid status, inflammation and hemostasis biomarkers in SAT. Methods: We included 52 patients (40 women and 12 men) treated with non-steroidal anti-inflammatory drugs (NSAID) or methylprednisolone (MPS). Free thyroxine (fT4), thyroid stimulating hormone, C-reactive protein, complete...

Preuzmite dokument 2024 Filiz Mercantepe , Jelena Vekic , Neda Milinkovic , Sanja Gluscevic , Jelena Kotur-Stevuljevic , Aleksandra Klisic , Serpil Ciftel

MDPI AG

Cardiometabolic Risk Factors Related to Atrial Fibrillation and Metabolic Syndrome in the Pakistani Population

Background and Objectives: This study aimed to examine the relationship between cardiometabolic risk factors and atrial fibrillation (AF) and the simultaneous presence of AF and metabolic syndrome (MetS) in the Pakistani population. Materials and Methods: A total of 690 subjects were enrolled (n = 230 patients with AF, n = 230 patients with AF and MetS, and n = 230 controls). The associations between cardiometabolic parameters and AF with and without MetS were analyzed by univariable and multivariable...

Preuzmite dokument 2024 Saima Sharif , Shagufta Naz , Filiz Mercantepe , Sanja Gluscevic , Saira Rafaqat , Aleksandra Klisic , Ana Ninic

Termedia Sp. z.o.o.

Interleukins: pathophysiological role in acute pancreatitis

Acute pancreatitis (AP) is a common inflammatory state characterized by a clinical course that can lead to serious local and extrapancreatic organ malfunction and failure. Interleukins (ILs) are biologically active glycoproteins primarily produced by macrophages and lymphocytes. According to the literature, there are many ILs. However, this article represents a summary of the role of ILs in AP, such as IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-11, IL-12, IL-13, IL-14, IL-15,...

Preuzmite dokument 2024 Saima Sharif , Saira Rafaqat , Amir Hossein Behnoush , Aleksandra Klisic , Dimitrios Patoulias

MDPI AG

Interleukins: Pathogenesis in Non-Alcoholic Fatty Liver Disease

Inflammatory cytokines have been implicated as crucial contributors to the onset and progression of non-alcoholic fatty liver disease (NAFLD). The exact mechanisms by which interleukins (ILs) contribute to NAFLD may vary, and ongoing research is aimed at understanding the specific roles of different ILs in the pathogenesis of this condition. In addition, variations in environmental factors and genetics in each individual can influence the onset and/or progression of NAFLD. The lack of clinical studies...

Preuzmite dokument 2024 Filiz Mercantepe , Sana Rafaqat , Sanja Gluscevic , Saira Rafaqat , Aleksandra Klisic

MDPI AG

The Association between Coagulation and Atrial Fibrillation

The existing literature highlights the presence of numerous coagulation factors and markers. Elevated levels of coagulation factors are associated with both existing and newly diagnosed cases of atrial fibrillation (AF). However, this article summarizes the role of coagulation in the pathogenesis of AF, which includes fibrinogen and fibrin, prothrombin, thrombomodulin, soluble urokinase plasminogen activator receptor, von Willebrand factor, P-selectin, D-dimer, plasminogen activator inhibitor-1,...

Preuzmite dokument 2024 Saima Sharif , Sanja Gluscevic , Saira Rafaqat , Aleksandra Klisic , Dimitrios Patoulias

MDPI AG

Redox Status and Telomere–Telomerase System Biomarkers in Patients with Acute Myocardial Infarction Using a Principal Component Analysis: Is There a Link?

In the present study, we examined redox status parameters in arterial and venous blood samples, its potential to predict the prognosis of acute myocardial infarction (AMI) patients assessed through its impact on the comprehensive grading SYNTAX score, and its clinical accuracy. Potential connections between common blood biomarkers, biomarkers of redox status, leukocyte telomere length, and telomerase enzyme activity in the acute myocardial infarction burden were assessed using principal component...

Preuzmite dokument 2023 Milica Stefanović , Srdjan Kafedžić , Aleksandar N. Nešković , Saša Hinić , Ivan Ilić , Barbara Ostanek , Miron Sopić , Nataša Bogavac-Stanojević , Janja Marc , Marija Zdravković , ... Pogledajte sve

Bentham Science Publishers Ltd.

The Link between miRNAs and PCKS9 in Atherosclerosis

Abstract: Cardiovascular disease (CDV) represents the major cause of death globally. Atherosclerosis, as the primary cause of CVD, is a chronic immune-inflammatory disorder with complex multifactorial pathophysiology encompassing oxidative stress, enhanced immune-inflammatory cascade, endothelial dysfunction, and thrombosis. An initiating event in atherosclerosis is the subendothelial accumulation of low-density lipoprotein (LDL), followed by the localization of macrophages to fatty deposits on...

Preuzmite dokument 2023 Jasjit Suri , Esma Isenovic , Manfredi Rizzo , Mirjana Macvanin , Zoran Gluvic , Mia Manojlovic , Aleksandra Klisic

Wiley

Effect of tirzepatide on albuminuria levels and renal function in patients with type 2 diabetes mellitus: A systematic review and multilevel meta‐analysis

AbstractAimThe present systematic review aimed to summarize the available evidence from published randomized controlled trials (RCTs) regarding the effect of tirzepatide on albuminuria levels and renal function in patients with type 2 diabetes mellitus.Materials and MethodsMedline (via PubMed), Cochrane Library and Scopus were searched until 20 October 2023. Double‐independent study selection, data extraction and quality assessment were performed. Evidence was pooled with a three‐level mixed‐effects...

Preuzmite dokument 2023 Paschalis Karakasis , Manfredi Rizzo , Nikolaos Fragakis , Aleksandra Klisic , Dimitrios Patoulias

MDPI AG

The Role of Endocan in Cardiometabolic Disorders

Discovered two decades ago, endocan still represents an intriguing biomarker related to inflammation. Endocan is a soluble dermatan sulphate proteoglycan secreted by endothelial cells. Its expression is observed in tissues related to the enhanced proliferation, especially hepatocytes, lungs, kidneys, etc. Endocan has been investigated in many cardiometabolic disorders that are tightly connected with inflammation, such as type 2 diabetes mellitus, hypertension, atherosclerotic cardiovascular disease,...

Preuzmite dokument 2023 Aleksandra Klisic , Dimitrios Patoulias

SAGE Publications

Treatment with Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors (PCSK9i): Current Evidence for Expanding the Paradigm?

Background: Proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) are low-density lipoprotein cholesterol (LDL-C)-lowering drugs that play a critical role in lipoprotein clearance and metabolism. PCSK9i are used in patients with familial hypercholesterolemia and for the secondary prevention of acute cardiovascular events in patients with atherosclerotic cardiovascular disease (CVD). Methods: We focused on the literature from 2015, the year of approval of the PCSK9 monoclonal antibodies,...

Preuzmite dokument 2023 Emir M. Muzurović , Manfredi Rizzo , Angelo Maria Patti , Manyoo A. Agarwal , Wael Almahmeed , Rosaria Vincenza Giglio , Aleksandra Klisic , Peter P. Toth , Marcello Ciaccio