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MDPI AG
From Metabolism to Longevity: Molecular Mechanisms Underlying Metformin’s Anticancer and Anti-Aging Effects
Metformin has stood as the primary clinical tool for type 2 diabetes for decades, yet its potential reach into oncology and gerontology is only now being critically dissected. This review evaluates how metformin might actually pull the levers of cancer progression and biological aging. Evidence from across various models suggests that the drug works by recalibrating cellular energy homeostasis—specifically by triggering AMPK and dampening the mTOR pathway. This signaling shift ripples through downstream...
Preuzmite dokument 2026 Stasa Scepanovic , Svetlana Perović , Slavica Vujovic , Andjelka Scepanovic , Milorad Vlaović
National Library of Serbia
Diagnostic validity of a marker model of first trimester in pregnancy in prediction of birth weight
Background/Aim. Nowadays, low birth weight is considered to be one of the main causes of cardiovascular diseases or metabolic syndrome occurring later in life. Many studies have shown a strong impact of abnormal birth weight onto the future development, however, due to its stronger influence onto the development, a special emphasis is placed on low birth weight as compared to higher one. There is still no high-percentage accuracy test that will clearly classify expectant women under the risk of...
Preuzmite dokument 2022 Milan Terzic , Slavica Vujovic , Andjelka Scepanovic , Milena Djurovic
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