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Walter de Gruyter GmbH
ABCB1 polymorphism in clopidogrel-treated Montenegrin patients
Abstract Clopidogrel is an antiplatelet drug that displays significant interindividual variability in treatment response. Its bioavailability depends on the function of P-glycoprotein (P-gp), which is coded by a highly polymorphic ABCB1 gene. Thus, the aim of this study was to investigate the effect of ABCB1 genetic polymorphism on clopidogrel efficacy and safety and to determine the frequency distribution of its most common single nucleotide polymorphisms (SNPs) in 106 Montenegrin...
Preuzmite dokument 2021 Natasa Djordjevic , Majda Sahman-Zaimovic , Snezana Mugosa , Zoran Todorovic , Jelena Cukic
National Library of Serbia
Adverse drug reactions associated with sunitinib therapy: Characteristics and risk factors
Background/Aim. Kidney tumors account for 2?3% of all tumors. Renal cell carcinoma (RCC) is the tenth most common malignancy. Sunitinib is used as the first treatment line in patients with a good and intermediate prognosis. The aim of this study was to analyze the risk factors, frequency, and adverse drug reactions (ADRs) of sunitinib in patients with metastatic RCC. Methods. The retrospective study included 170 patients treated at the Clinic for Oncology of the Clinical Center of Montenegro, Urology...
Preuzmite dokument 2021 Majda Sahman-Zaimovic , Nevenka Lukovac-Janjic , Zoran Dzamic , Snezana Mugosa
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