Digital platoform

Bentham Science Publishers Ltd.

Therapeutic Potential of Sodium-glucose Co-transporter-2 Inhibitors and Glucagon-like Peptide-1 Receptor Agonists for Patients with Acute Coronary Syndrome: A Review of Clinical Evidence

: Atherosclerotic Cardiovascular Disease (ASCVD) is still one of the leading causes of death globally, with Coronary Artery Disease (CAD) being the most prevalent form of ASCVD. Patients with type 2 Diabetes Mellitus (DM) experience an increased risk for ASCVD during the disease course, with CAD being the most common cause of death among affected individuals, resulting in shorter life expectancy and increased morbidity among survivors. Recently, 2 novel classes of anti-diabetic drugs, namely Sodium-Glucose...

Preuzmite dokument 2024 Paschalis Karakasis , Manfredi Rizzo , Nikolaos Fragakis , Theocharis Koufakis , Michael Doumas , Aleksandra Klisic , Dimitrios Patoulias , George Kassimis

MDPI AG

The Effects of Sodium-Glucose Cotransporter 2-Inhibitors on Steatosis and Fibrosis in Patients with Non-Alcoholic Fatty Liver Disease or Steatohepatitis and Type 2 Diabetes: A Systematic Review of Randomized Controlled Trials

Type 2 Diabetes Mellitus (T2DM) and non-alcoholic fatty liver disease (NAFLD) are part of metabolic syndrome and share multiple causal associations. Both conditions have an alarmingly increasing incidence and lead to multiple complications, which have an impact on a variety of organs and systems, such as the kidneys, eyes, and nervous and cardiovascular systems, or may cause metabolic disruptions. Sodium-glucose cotransporter 2-inhibitors (SGLT2-i), as an antidiabetic class with well-established...

Preuzmite dokument 2023 Roxana Adriana Stoica , Anca Pantea Stoian , Manfredi Rizzo , Andrej Janež , Špela Volčanšek , Djordje Popovic , Emir Muzurović , Teodor Salmen , Ioana-Cristina Bica

Bentham Science Publishers Ltd.

The Link between miRNAs and PCKS9 in Atherosclerosis

Abstract: Cardiovascular disease (CDV) represents the major cause of death globally. Atherosclerosis, as the primary cause of CVD, is a chronic immune-inflammatory disorder with complex multifactorial pathophysiology encompassing oxidative stress, enhanced immune-inflammatory cascade, endothelial dysfunction, and thrombosis. An initiating event in atherosclerosis is the subendothelial accumulation of low-density lipoprotein (LDL), followed by the localization of macrophages to fatty deposits on...

Preuzmite dokument 2023 Jasjit Suri , Esma Isenovic , Manfredi Rizzo , Mirjana Macvanin , Zoran Gluvic , Mia Manojlovic , Aleksandra Klisic

Wiley

Effect of tirzepatide on albuminuria levels and renal function in patients with type 2 diabetes mellitus: A systematic review and multilevel meta‐analysis

AbstractAimThe present systematic review aimed to summarize the available evidence from published randomized controlled trials (RCTs) regarding the effect of tirzepatide on albuminuria levels and renal function in patients with type 2 diabetes mellitus.Materials and MethodsMedline (via PubMed), Cochrane Library and Scopus were searched until 20 October 2023. Double‐independent study selection, data extraction and quality assessment were performed. Evidence was pooled with a three‐level mixed‐effects...

Preuzmite dokument 2023 Paschalis Karakasis , Manfredi Rizzo , Nikolaos Fragakis , Aleksandra Klisic , Dimitrios Patoulias

SAGE Publications

Treatment with Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors (PCSK9i): Current Evidence for Expanding the Paradigm?

Background: Proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) are low-density lipoprotein cholesterol (LDL-C)-lowering drugs that play a critical role in lipoprotein clearance and metabolism. PCSK9i are used in patients with familial hypercholesterolemia and for the secondary prevention of acute cardiovascular events in patients with atherosclerotic cardiovascular disease (CVD). Methods: We focused on the literature from 2015, the year of approval of the PCSK9 monoclonal antibodies,...

Preuzmite dokument 2023 Emir M. Muzurović , Manfredi Rizzo , Angelo Maria Patti , Manyoo A. Agarwal , Wael Almahmeed , Rosaria Vincenza Giglio , Aleksandra Klisic , Peter P. Toth , Marcello Ciaccio

SAGE Publications

Quality of Life in People with Diabetes Mellitus and Unilateral Transtibial Amputation - Aspects of Using the Berg Balance Scale

Approximately 40%-60% of all amputations are lower limb amputations (LLAs) related to diabetes mellitus (DM). The importance of quality of life (QoL) is increasingly recognized as after amputation. The objective of this cross-sectional study was to compare QoL (evaluated by Berg Balance Scale, BBS) in DM patients with unilateral transtibial amputation (TTA) using prosthesis (group A) with that of patients amputated due to other causes (group B). Overall, 32 patients completed two questionnaires:...

Preuzmite dokument 2023 Manfredi Rizzo , Nikolaos Papanas , Sonja Nejkov , Emir Muzurović , Vesna Bokan