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Walter de Gruyter GmbH
Risk factors for adverse drug reactions associated with clopidogrel therapy
Abstract This study aimed to investigate the possible influence of genetic and non-genetic factors on the incidence of clopidogrel adverse drug reactions (ADRs) in cardiology patients, including the most important CYP2C19 alleles, namely *2 and *17, as well as compliance, dose, drug interactions, and clinical factors. A total of 102 clopidogrel-treated adult Caucasian patients hospitalized at the Cardiology Department of the Clinical Center of Montenegro were enrolled in the study....
Preuzmite dokument 2022 Ivan Radosavljevic , Natasa Djordjevic , Majda Sahman , Snezana Mugosa , Zoran Todorovic
Walter de Gruyter GmbH
ABCB1 polymorphism in clopidogrel-treated Montenegrin patients
Abstract Clopidogrel is an antiplatelet drug that displays significant interindividual variability in treatment response. Its bioavailability depends on the function of P-glycoprotein (P-gp), which is coded by a highly polymorphic ABCB1 gene. Thus, the aim of this study was to investigate the effect of ABCB1 genetic polymorphism on clopidogrel efficacy and safety and to determine the frequency distribution of its most common single nucleotide polymorphisms (SNPs) in 106 Montenegrin...
Preuzmite dokument 2021 Natasa Djordjevic , Majda Sahman-Zaimovic , Snezana Mugosa , Zoran Todorovic , Jelena Cukic
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