Interleukins: Pathogenesis in Non-Alcoholic Fatty Liver Disease

MDPI AG

Filiz Mercantepe , Sana Rafaqat , Sanja Gluscevic , Saira Rafaqat , Aleksandra Klisic

2024

Inflammatory cytokines have been implicated as crucial contributors to the onset and progression of non-alcoholic fatty liver disease (NAFLD). The exact mechanisms by which interleukins (ILs) contribute to NAFLD may vary, and ongoing research is aimed at understanding the specific roles of different ILs in the pathogenesis of this condition. In addition, variations in environmental factors and genetics in each individual can influence the onset and/or progression of NAFLD. The lack of clinical studies related to the potential therapeutic properties of IL-1 inhibitors currently does not allow us to conclude their validity as a therapeutic option, although preclinical studies show promising results. Further studies are needed to elucidate their beneficial properties in NAFLD treatment.

MDPI AG

The Potential Role of sPD-L1 as a Predictive Biomarker in EGFR-Positive Non-Small-Cell Lung Cancer

Background/Objectives: A significant breakthrough in non-small-cell lung cancer (NSCLC) treatment has occurred with the introduction of targeted therapies and immunotherapy. However, not all patients treated with these therapies would respond to treatment, and patients who respond to treatment would acquire resistance at some time point. This is why we need new biomarkers that can predict response to therapy. The aim of this study was to investigate whether soluble programmed cell death-ligand 1...

Preuzmite dokument 2025 Ivan Soldatović , Damir Radončić , Biljana Šeha , Dragana Jovanović , Milan Savić , Natalija Samardžić , Aleksandra Klisic , Jelena Kotur Stevuljević , Milija Gajić , Marina Roksandić Milenković , ... Pogledajte sve

Informa UK Limited

Treatment options for heart failure in individuals with overweight or obesity: a review

Preuzmite dokument 2025 Paschalis Karakasis , Efstratios Karagiannidis , Nikolaos Fragakis , Theocharis Koufakis , Christos Kofos , Athina Nasoufidou , Aleksandra Klisic , Djordje S. Popovic , Panagiotis Stachteas , Dimitrios Patoulias

Wiley

Sodium‐glucose cotransporter 2 inhibitors and outcomes in transthyretin amyloid cardiomyopathy: Systematic review and meta‐analysis

AbstractBackgroundTransthyretin amyloid cardiomyopathy (ATTR‐CM) commonly leads to heart failure but has traditionally been an exclusion criterion in randomized clinical trials (RCTs) of sodium‐glucose cotransporter 2 inhibitors (SGLT2i); therefore, the effects of these drugs in this population remain undocumented. In light of recent studies, this meta‐analysis aimed to investigate the effect of SGLT2i on the prognosis of patients with ATTR‐CM.MethodsA comprehensive search of Medline, Scopus, and...

Preuzmite dokument 2025 Paschalis Karakasis , Panagiotis Theofilis , Manfredi Rizzo , Nikolaos Fragakis , Panayotis K Vlachakis , Aleksandra Klisic , Dimitrios Patoulias , Art Schuermans

MDPI AG

Expression Analysis of Circulating miR-21, miR-34a and miR-122 and Redox Status Markers in Metabolic Dysfunction-Associated Steatotic Liver Disease Patients with and Without Type 2 Diabetes

Metabolic dysfunction-associated steatotic liver disease (MASLD), a hepatic form of metabolic syndrome, often co-occurs with type 2 diabetes (T2D) and now affects approximately 30% of the global population. MASLD encompasses conditions from simple steatosis to metabolic dysfunction-associated steatohepatitis, with oxidative stress (OS) driving progression through inflammation. This study analyzes the expression levels of circulating miRNAs and redox status markers in MASLD patients with and without...

Preuzmite dokument 2025 Sanja Erceg , Sanja Vujcic , Miron Sopić , Miloš Mitrović , Jelena Kotur-Stevuljevic , Aleksandra Klisic , Milica Mamić , Ana Ninic , Jelena Munjas , Ratko Tomašević

Bentham Science Publishers Ltd.

Therapeutic Potential of Sodium-glucose Co-transporter-2 Inhibitors and Glucagon-like Peptide-1 Receptor Agonists for Patients with Acute Coronary Syndrome: A Review of Clinical Evidence

: Atherosclerotic Cardiovascular Disease (ASCVD) is still one of the leading causes of death globally, with Coronary Artery Disease (CAD) being the most prevalent form of ASCVD. Patients with type 2 Diabetes Mellitus (DM) experience an increased risk for ASCVD during the disease course, with CAD being the most common cause of death among affected individuals, resulting in shorter life expectancy and increased morbidity among survivors. Recently, 2 novel classes of anti-diabetic drugs, namely Sodium-Glucose...

Preuzmite dokument 2024 Paschalis Karakasis , Manfredi Rizzo , Nikolaos Fragakis , Theocharis Koufakis , Michael Doumas , Aleksandra Klisic , Dimitrios Patoulias , George Kassimis