Interleukins: Pathogenesis in Non-Alcoholic Fatty Liver Disease

MDPI AG

Filiz Mercantepe , Sana Rafaqat , Sanja Gluscevic , Saira Rafaqat , Aleksandra Klisic

2024

Inflammatory cytokines have been implicated as crucial contributors to the onset and progression of non-alcoholic fatty liver disease (NAFLD). The exact mechanisms by which interleukins (ILs) contribute to NAFLD may vary, and ongoing research is aimed at understanding the specific roles of different ILs in the pathogenesis of this condition. In addition, variations in environmental factors and genetics in each individual can influence the onset and/or progression of NAFLD. The lack of clinical studies related to the potential therapeutic properties of IL-1 inhibitors currently does not allow us to conclude their validity as a therapeutic option, although preclinical studies show promising results. Further studies are needed to elucidate their beneficial properties in NAFLD treatment.

Bentham Science Publishers Ltd.

Therapeutic Potential of Sodium-glucose Co-transporter-2 Inhibitors and Glucagon-like Peptide-1 Receptor Agonists for Patients with Acute Coronary Syndrome: A Review of Clinical Evidence

: Atherosclerotic Cardiovascular Disease (ASCVD) is still one of the leading causes of death globally, with Coronary Artery Disease (CAD) being the most prevalent form of ASCVD. Patients with type 2 Diabetes Mellitus (DM) experience an increased risk for ASCVD during the disease course, with CAD being the most common cause of death among affected individuals, resulting in shorter life expectancy and increased morbidity among survivors. Recently, 2 novel classes of anti-diabetic drugs, namely Sodium-Glucose...

Preuzmite dokument 2024 Paschalis Karakasis , Manfredi Rizzo , Nikolaos Fragakis , Theocharis Koufakis , Michael Doumas , Aleksandra Klisic , Dimitrios Patoulias , George Kassimis

Wiley

Effects of glucagon‐like peptide‐1 receptor agonists on glycated haemoglobin and continuous glucose monitoring metrics as adjunctive therapy to insulin in adults with type 1 diabetes: A meta‐analysis of randomized controlled trials

AbstractAimsTo conduct a meta‐analysis of randomized controlled trials (RCTs) to evaluate the effect of glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) on glycated haemoglobin (HbA1c) and continuous glucose monitoring (CGM) metrics as an adjunct to insulin therapy in adults with type 1 diabetes mellitus (T1D).MethodsA systematic literature search was conducted through Medline (via PubMed), Cochrane Library, and Google Scholar up to 27 May 2024. Dual‐independent study selection, data extraction,...

Preuzmite dokument 2024 Paschalis Karakasis , Fotios Barkas , Theocharis Koufakis , Michael Doumas , Nikolaos Papanas , Aleksandra Klisic , Djordje S. Popovic , Milena Mitrovic , Dimitrios Patoulias

Mary Ann Liebert Inc

Are Oxidative Stress Biomarkers Reliable Part of Multimarker Panel in Female Patients with Type 2 Diabetes Mellitus?

Preuzmite dokument 2024 Paschalis Karakasis , Amirmohammad Khalaji , Aleksandra Klisic , Ana Ninic , Dimitrios Patoulias

MDPI AG

Investigating the Hepatic Response to Orlistat and White Tea in Rats on a High-Fat Diet

High-fat diets have detrimental health impacts that increase the likelihood of developing obesity and metabolic syndrome. This study aimed to examine the potential antioxidant and anti-inflammatory effects of orlistat and white tea in rats fed a high-fat diet. Thirty-two rats were randomized into four groups: control (standard diet), HFD (high-fat diet), HFD+Orlistat (high-fat diet+orlistat), and HFD+WT (high-fat diet+white tea extract). A significant increase in malondialdehyde (MDA) levels and...

Preuzmite dokument 2024 Adnan Yilmaz , Merve Nur Toraman , Filiz Mercantepe , Sedat Ciftel , Esra Pinarbas , Enver Ciftel , Aleksandra Klisic , Serpil Ciftel , Tolga Mercantepe

MDPI AG

Cardiovascular Risk in Patients with Ankylosing Spondylitis

Objectives: Ankylosing spondylitis (AS) is an autoinflammatory, chronic disease. Patients with AS are at increased risk of cardiovascular disease (CVD). The link between AS and subclinical atherosclerosis is multifactorial and still not completely understood. The aim of this study was to examine the potential associations between carotid intima–media thickness (cIMT) and different cardiometabolic biomarkers in individuals with AS. Methods: A total of 96 patients with AS were prospectively included....

Preuzmite dokument 2024 Filiz Mercantepe , Osman Cure , Bayram Kizilkaya , Jelena Kotur-Stevuljevic , Aleksandra Klisic , Fatma Beyazal Celiker , Huseyin Er