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Natural and natural-like polyphenol compounds: in vitro antioxidant activity and potential for therapeutic application
IntroductionPhenols are a large family of natural and synthetic compounds with known antioxidant activity. The aim of this study was to preform an in vitro screening of natural and natural-like phenol monomers and their C2-symetric dimers (hydroxylated biphenyls) in order to identify those representatives which pharmacophores have the strongest antioxidant and the lowest prooxidant activity.Material and methodsAntioxidative properties of 36 compounds (monomers and their C2-symmetric dimers) were...
Download 2021 Paola Carta , Giovanna Delogu , Darinka Gjorgieva Ackova , Jelena Kotur-Stevuljevic , Aleksandra Klisic , Jasmina Brboric , Maria Antonietta Dettori , Luciano Saso , Kristina Kostic , Davide Fabbri
Hindawi Limited
Factorial Analysis of the Cardiometabolic Risk Influence on Redox Status Components in Adult Population
Different byproducts of oxidative stress do not always lead to the same conclusion regarding its relationship with cardiometabolic risk, since controversial results are reported so far. The aim of the current study was to examine prooxidant determinant ((prooxidant-antioxidant balance (PAB)) and the marker of antioxidant defence capacity (total sulphydryl groups (tSHG)), as well as their ratio (PAB/tSHG) in relation to different cardiometabolic risk factors in the cohort of adult population. Additionally,...
Download 2021 Sanja Vujcic , Nebojsa Kavaric , Jelena Kotur-Stevuljevic , Aleksandra Klisic , Ana Ninic , Vesna Spasojevic-Kalimanovska
Research Square Platform LLC
Oxidative Stress and Cardiometabolic Biomarkers in Patients with Non-alcoholic Fatty Liver Disease
Abstract Objective: Oxidative stress is assumed to be the underlying feature of non-alcoholic fatty liver disease (NAFLD). To our knowledge, the mutual involvement of redox status homeostasis parameters [i.e., advanced oxidation protein products (AOPP), pro-oxidant-antioxidant balance (PAB), total oxidant status (TOS), total antioxidant status (TAS) and oxidative-stress index (OSI)] and cardiometabolic biomarkers in subjects with NAFLD has not been examined yet. Accordingly, we aimed to...
Download 2021 Nebojsa Kavaric , Jelena Kotur-Stevuljevic , Aleksandra Klisic , Ana Ninic
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