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MDPI AG
Essential Oil of Prangos ferulacea (L.) Lindl.: Chemistry and Bioactivities
Prangos ferulacea (L.) Lindl. (Apiaceae) is an orophilous species with notable traditional uses, particularly across the broader Middle East region. Over the past 50 years, research on its essential oil has revealed the existence of several chemotypes. In addition to its chemical composition, there is also data on the biological activities of the essential oil. Among these activities, the most extensively studied are its antimicrobial and, to a lesser extent, antioxidant properties. Recent findings...
Download 2026 Rino Ragno , Vanja Tadić , Milan Mladenović , Mijat Božović
MDPI AG
Phenolic Compounds, Antioxidant and Antimicrobial Activities of Punica granatum L. Fruit Extracts
Pomegranate is valued for its abundant polyphenolic content and its capacity to promote health. In this study, pomegranate juice or pericarp extracts from two Mediterranean regions (Montenegro and Italy) were systematically and comparatively evaluated for the first time with respect to their polyphenolic composition, antioxidant capacity, and antimicrobial activity. The extraction of juice extracts was accomplished by means of the Kutscher–Steudel liquid–liquid extraction technique, which was employed...
Download 2026 Roberta Astolfi , Rino Ragno , Vanja Tadić , Milan Mladenović , Mijat Božović , Alessandra Oliva
SAGE Publications
Phenolic Content and Antioxidant Potential of Wine Extracts
Background/Objective: Phenolic compounds are considered to be the most important parameters of wine quality, contributing not only to its organoleptic characteristics, but to various health benefits associated with wine consumption. Although these are successfully extracted from grapes and winemaking by-products, there is no data on extraction from wine itself. This is particularly interesting in light of the fact that the variability of wine polyphenols is not only attributed...
Download 2025 Dragana Petrović , Rino Ragno , Milan Mladenović , Mijat Božović , Danka Caković
MDPI AG
Chemical Composition and Anti-Candida Activity of Mentha suaveolens Ehrh. Essential Oils Obtained by Different Distillation Processes
A comparative study on essential oils extracted from Mentha suaveolens Ehrh. from Italy is reported. Two extraction procedures were investigated: hydrodistillation and steam distillation, carried out as a continuous and fractionated procedure. Fresh and dried plant material from two harvests was used. The hydrodistillation method yielded a higher amount of essential oil. The dried plant was significantly richer in essential oil per kg of starting plant material. Gas chromatography-mass spectrometry...
Download 2023 Roberta Astolfi , Maria Cristina Zaka , Stefano Manfredini , Silvia Vertuani , Rino Ragno , Vanja Tadić , Caterina Fraschetti , Milan Mladenović , Mijat Božović , Filippo Sapienza , Francesca Borzacchi , Caterina Rossi , Fabiana Del Bove , Anna Baldisserotto ... Pogledajte sve
MDPI AG
Molecular Docking Assessment of Cathinones as 5-HT2AR Ligands: Developing of Predictive Structure-Based Bioactive Conformations and Three-Dimensional Structure-Activity Relationships Models for Future Recognition of Abuse Drugs
Commercially available cathinones are drugs of long-term abuse drugs whose pharmacology is fairly well understood. While their psychedelic effects are associated with 5-HT2AR, the enclosed study summarizes efforts to shed light on the pharmacodynamic profiles, not yet known at the receptor level, using molecular docking and three-dimensional quantitative structure–activity relationship (3-D QSAR) studies. The bioactive conformations of cathinones were modeled by AutoDock Vina and were used to build...
Download 2023 Sanja Lj. Matić , Eleonora Proia , Nevena Tomašević , Emilija Kostić , Maja Vujović , Rino Ragno , Milan Mladenović , Mijat Božović , Venkatesan Ragavendran , Rossella Fioravanti , Biljana Arsić ... Pogledajte sve
MDPI AG
In Vitro Antioxidant and In Vivo Antigenotoxic Features of a Series of 61 Essential Oils and Quantitative Composition–Activity Relationships Modeled through Machine Learning Algorithms
The antioxidant activity of essential oils (EOs) is an important and frequently studied property, yet it is not sufficiently understood in terms of the contribution of EOs mixtures’ constituents and biological properties. In this study, a series of 61 commercial EOs were first evaluated as antioxidants in vitro, following as closely as possible the cellular pathways of reactive oxygen species (ROS) generation. Hence, EOs were assessed for the ability either to chelate metal ions, thus interfering...
Download 2023 Roberta Astolfi , Nevena Tomašević , Rino Ragno , Milan Mladenović , Mijat Božović , Filippo Sapienza , Sanja Matić
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