Nazad
MDPI AG
Interleukins: Pathogenesis in Non-Alcoholic Fatty Liver Disease
Filiz Mercantepe , Sana Rafaqat , Sanja Gluscevic , Saira Rafaqat , Aleksandra Klisic
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2024
Inflammatory cytokines have been implicated as crucial contributors to the onset and progression of non-alcoholic fatty liver disease (NAFLD). The exact mechanisms by which interleukins (ILs) contribute to NAFLD may vary, and ongoing research is aimed at understanding the specific roles of different ILs in the pathogenesis of this condition. In addition, variations in environmental factors and genetics in each individual can influence the onset and/or progression of NAFLD. The lack of clinical studies related to the potential therapeutic properties of IL-1 inhibitors currently does not allow us to conclude their validity as a therapeutic option, although preclinical studies show promising results. Further studies are needed to elucidate their beneficial properties in NAFLD treatment.
MDPI AG
Role of Interleukins in Type 1 and Type 2 Diabetes
Background: Despite distinct etiologies, type 1 diabetes (T1D) and type 2 diabetes (T2D) share chronic inflammation as a core feature. Interleukins, key immune mediators, play important yet still not fully understood roles in the development and complications of both conditions. Objective: This narrative review aims to provide a comprehensive and critical synthesis of current evidence on the role of key interleukins in T1D and T2D, highlighting their immunological functions, genetic associations,...
Download 2025 Filiz Mercantepe , Sana Rafaqat , Saira Rafaqat , Aleksandra Klisic , Roha Asif , Ammara Khalid , Tolga Mercantepe
MDPI AG
Association of Serum Selenium with Clinical Features and Inflammatory and Oxidative Stress Markers in Iranian Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease—A Cross-Sectional Study
Background: There are conflicting epidemiological studies regarding the association between selenium (Se) and metabolic disorders. Furthermore, the pathophysiological links between Se and metabolic dysfunction-associated steatotic liver disease (MASLD) have not yet been fully elucidated. Therefore, we evaluated the association between serum Se levels and the clinical features of MASLD and the inflammatory and oxidative stress markers in these patients as potential risk factors for the progression...
Download 2025 Reza Sharifi , Abbas Pishdadian , Soudabeh Hamedi-Shahraki , Aleksandra Klisic , Farshad Amirkhizi , Adele Shafaghi
MDPI AG
The Potential Role of sPD-L1 as a Predictive Biomarker in EGFR-Positive Non-Small-Cell Lung Cancer
Background/Objectives: A significant breakthrough in non-small-cell lung cancer (NSCLC) treatment has occurred with the introduction of targeted therapies and immunotherapy. However, not all patients treated with these therapies would respond to treatment, and patients who respond to treatment would acquire resistance at some time point. This is why we need new biomarkers that can predict response to therapy. The aim of this study was to investigate whether soluble programmed cell death-ligand 1...
Download 2025 Ivan Soldatović , Damir Radončić , Biljana Šeha , Dragana Jovanović , Milan Savić , Natalija Samardžić , Aleksandra Klisic , Jelena Kotur Stevuljević , Milija Gajić , Marina Roksandić Milenković , Nikola Čolić , Katarina Lukić , Vesna Ceriman Krstic ... Pogledajte sve
Informa UK Limited
Treatment options for heart failure in individuals with overweight or obesity: a review
Download 2025 Paschalis Karakasis , Efstratios Karagiannidis , Nikolaos Fragakis , Theocharis Koufakis , Christos Kofos , Athina Nasoufidou , Aleksandra Klisic , Djordje S. Popovic , Panagiotis Stachteas , Dimitrios Patoulias
Wiley
Sodium‐glucose cotransporter 2 inhibitors and outcomes in transthyretin amyloid cardiomyopathy: Systematic review and meta‐analysis
AbstractBackgroundTransthyretin amyloid cardiomyopathy (ATTR‐CM) commonly leads to heart failure but has traditionally been an exclusion criterion in randomized clinical trials (RCTs) of sodium‐glucose cotransporter 2 inhibitors (SGLT2i); therefore, the effects of these drugs in this population remain undocumented. In light of recent studies, this meta‐analysis aimed to investigate the effect of SGLT2i on the prognosis of patients with ATTR‐CM.MethodsA comprehensive search of Medline, Scopus, and...
Download 2025 Paschalis Karakasis , Panagiotis Theofilis , Manfredi Rizzo , Nikolaos Fragakis , Panayotis K Vlachakis , Aleksandra Klisic , Dimitrios Patoulias , Art Schuermans
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Copyright © 2025 EmpowerHR4Inno. All right reserved.
Copyright © 2025 EmpowerHR4Inno. All rights reserved.