MDPI AG
Transcriptomic, Redox Status and Adipocytokine Profiles in Metabolic Dysfunction-Associated Steatotic Liver Disease: Impact of Coexisting Type 2 Diabetes
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) commonly coexists with type 2 diabetes (T2D), but their independent contributions to redox imbalance, inflammation and immune signaling remain uncertain. Objectives: This study aimed to evaluate whether the presence of MASLD alone, and the presence of T2D within MASLD, are independently associated with high-risk profiles of oxidative/antioxidant markers, peripheral blood mononuclear cell (PBMC) gene expression and adipocytokines....
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2025
Sanja Erceg
,
Miron Sopić
,
Boško Misita
,
Miloš Mitrović
,
Jelena Kotur-Stevuljevic
,
Aleksandra Klisic
,
Milica Mamić
,
Ana Ninic
,
Jelena Munjas
,
Omar Ben Mariem
,
Ratko Tomašević
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MDPI AG
SGLT2 Inhibitors in the Management of Cardio-Renal-Metabolic Syndrome: A New Therapeutic Era
Cardiovascular (CV) disease, chronic kidney disease, obesity, and diabetes mellitus have reached epidemic proportions over the past few decades. Accumulating evidence highlights the strong interconnection between these conditions, leading to the definition of a broader disease entity known as cardio-renal-metabolic (CRM) syndrome. This newly recognized clinical entity presents important challenges in identifying the optimal treatment strategy within a holistic, patient-centered framework. In line...
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2025
Paschalis Karakasis
,
Efstratios Karagiannidis
,
Antonios P. Antoniadis
,
Nikolaos Fragakis
,
Athina Nasoufidou
,
Aleksandra Klisic
,
Konstantinos Grigoriou
,
Djordje S. Popovic
,
Panagiotis Stachteas
,
Dimitrios Patoulias
,
Barbara Fyntanidou
... Pogledajte sve