Endocan in nonalcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis

Informa UK Limited

Filiz Mercantepe , Alireza Yaghoobi , Sai Gautham Kanagala , Zahra Shokri Varniab , Amirmohammad Khalaji , Amir Hossein Behnoush , Elaheh Karimi , Aleksandra Klisic

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2025

MDPI AG

Association of Genetic Variants in PNPLA3, MBOAT7, and MARC1 with Metabolic and Hematological Immune-Inflammation Indices in Adolescent Females with and Without MASLD: A Multilevel Risk-Allele Burden Analysis

Metabolic dysfunction-associated steatotic liver disease (MASLD) is increasingly recognized during adolescence and exhibits sex-specific characteristics. Its prevalence in late adolescent females is around 10% in the general population and exceeds 30% in obesity. Genetic variants in PNPLA3, MBOAT7, and MARC1 modulate hepatic fat accumulation and liver injury in adults, but evidence in adolescent females remains limited. This study examined MASLD-related variants (PNPLA3 rs738409, MBOAT7 rs641738,...

Download 2026 Barbara Ostanek , Janja Marc , Aleksandra Klisic , Simona Jurkovic Jurkovic Mlakar

MDPI AG

A Narrative Review on Abnormalities in the Hemostatic System in Diabetes Mellitus: Pathophysiology, Clinical Implications, and Therapeutics

Diabetes mellitus (DM) is a complex metabolic disorder associated with a heightened risk of cardiovascular events, largely driven by a hypercoagulable and hypofibrinolytic state. The pathophysiological interplay between chronic hyperglycemia, oxidative stress, insulin resistance, and systemic inflammation fosters profound alterations in the coagulation cascade, endothelial function, and platelet activity. This narrative review synthesizes evidence from studies published between 2008 and 2026, focusing...

Download 2026 Filiz Mercantepe , Hafsa Hamid , Sana Rafaqat , Saira Rafaqat , Aleksandra Klisic , Hijab Abaid , Fakhra Bashir

Frontiers Media SA

Editorial: Molecular biomarkers of cardiometabolic disease - volume II

Download 2026 Mirjana Macvanin , Aleksandra Klisic

Journal of Medicine and Palliative Care

Associations of hsCRP, anthropometric, and biochemical parameters with cardiovascular risk in menopause status: a cross-sectional study

Aims: Cardiovascular disease (CVD) risk increases significantly after menopause, partly due to hormonal changes leading to abdominal obesity, dyslipidemia, and low-grade inflammation. High-sensitivity C-reactive protein (hsCRP) is a well-established biomarker of subclinical inflammation, yet its associations with anthropometric and biochemical parameters in menopausal women remain incompletely defined. To evaluate cardiovascular risk across hsCRP-based subgroups in menopausal women and identify...

Download 2025 Filiz Mercantepe , Aleksandra Klisic , Alev Lazoğlu Özkaya , Elma Kalac

MDPI AG

Transcriptomic, Redox Status and Adipocytokine Profiles in Metabolic Dysfunction-Associated Steatotic Liver Disease: Impact of Coexisting Type 2 Diabetes

Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) commonly coexists with type 2 diabetes (T2D), but their independent contributions to redox imbalance, inflammation and immune signaling remain uncertain. Objectives: This study aimed to evaluate whether the presence of MASLD alone, and the presence of T2D within MASLD, are independently associated with high-risk profiles of oxidative/antioxidant markers, peripheral blood mononuclear cell (PBMC) gene expression and adipocytokines....

Download 2025 Sanja Erceg , Miron Sopić , Boško Misita , Miloš Mitrović , Jelena Kotur-Stevuljevic , Aleksandra Klisic , Milica Mamić , Ana Ninic , Jelena Munjas , Omar Ben Mariem , ... Pogledajte sve