MDPI AG
Transcriptomic, Redox Status and Adipocytokine Profiles in Metabolic Dysfunction-Associated Steatotic Liver Disease: Impact of Coexisting Type 2 Diabetes
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) commonly coexists with type 2 diabetes (T2D), but their independent contributions to redox imbalance, inflammation and immune signaling remain uncertain. Objectives: This study aimed to evaluate whether the presence of MASLD alone, and the presence of T2D within MASLD, are independently associated with high-risk profiles of oxidative/antioxidant markers, peripheral blood mononuclear cell (PBMC) gene expression and adipocytokines....
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2025
Sanja Erceg
,
Miron Sopić
,
Boško Misita
,
Miloš Mitrović
,
Jelena Kotur-Stevuljevic
,
Aleksandra Klisic
,
Milica Mamić
,
Ana Ninic
,
Jelena Munjas
,
Omar Ben Mariem
,
Ratko Tomašević
... Pogledajte sve
MDPI AG
SGLT2 Inhibitors in the Management of Cardio-Renal-Metabolic Syndrome: A New Therapeutic Era
Cardiovascular (CV) disease, chronic kidney disease, obesity, and diabetes mellitus have reached epidemic proportions over the past few decades. Accumulating evidence highlights the strong interconnection between these conditions, leading to the definition of a broader disease entity known as cardio-renal-metabolic (CRM) syndrome. This newly recognized clinical entity presents important challenges in identifying the optimal treatment strategy within a holistic, patient-centered framework. In line...
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2025
Paschalis Karakasis
,
Efstratios Karagiannidis
,
Antonios P. Antoniadis
,
Nikolaos Fragakis
,
Athina Nasoufidou
,
Aleksandra Klisic
,
Konstantinos Grigoriou
,
Djordje S. Popovic
,
Panagiotis Stachteas
,
Dimitrios Patoulias
,
Barbara Fyntanidou
... Pogledajte sve
MDPI AG
Role of Interleukins in Type 1 and Type 2 Diabetes
Background: Despite distinct etiologies, type 1 diabetes (T1D) and type 2 diabetes (T2D) share chronic inflammation as a core feature. Interleukins, key immune mediators, play important yet still not fully understood roles in the development and complications of both conditions. Objective: This narrative review aims to provide a comprehensive and critical synthesis of current evidence on the role of key interleukins in T1D and T2D, highlighting their immunological functions, genetic associations,...
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2025
Filiz Mercantepe
,
Sana Rafaqat
,
Saira Rafaqat
,
Aleksandra Klisic
,
Roha Asif
,
Ammara Khalid
,
Tolga Mercantepe
