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MDPI AG
From Metabolism to Longevity: Molecular Mechanisms Underlying Metformin’s Anticancer and Anti-Aging Effects
Metformin has stood as the primary clinical tool for type 2 diabetes for decades, yet its potential reach into oncology and gerontology is only now being critically dissected. This review evaluates how metformin might actually pull the levers of cancer progression and biological aging. Evidence from across various models suggests that the drug works by recalibrating cellular energy homeostasis—specifically by triggering AMPK and dampening the mTOR pathway. This signaling shift ripples through downstream...
Preuzmite dokument 2026 Stasa Scepanovic , Svetlana Perović , Slavica Vujovic , Andjelka Scepanovic , Milorad Vlaović
Walter de Gruyter GmbH
Spiroplasmas as Causative Agents of Honey Bees Diseases
Abstract Spiroplasmas are bacteria that play a significant role in the development of bee diseases. Infections of bees with spiroplasmas have been registered in Europe, America and Asia, and such infections occur through contaminated food, the sting of Varroa destructor , and vertically. The most important species that cause bee spiroplasmosis are conditionally pathogenic bacteria Spiroplasma apis...
Preuzmite dokument 2026 Mirjana R. Bojanić Rašović
Državni arhiv u Šibeniku
Business Misunderstanding or Diplomatic Pressure
The paper examines a note from Leopold von Talman, the Austrian ambassador to Constantinople, addressed to the Republic of Dubrovnik on the eve of the Austro-Ottoman War of 1737. In June 1737, Talman was in Soroca, along the Dniester River, from where he sent this note to Dubrovnik. Talman was known for writing letters with conspiratorial themes, and it can be inferred that this letter served, among other purposes, as a warning to Dubrovnik to respect Austrian interests along the eastern Adriatic...
Preuzmite dokument 2026 Dalibor Elezović
MDPI AG
Remote Sensing and GIS Assessment of Drought Dynamics in the Ukrina River Basin, Bosnia and Herzegovina
The subject of this research is the exploration of the potential of remote sensing and Geographic Information Systems (GIS) for basin-scale spatio-temporal monitoring of drought and its impacts in the Ukrina River Basin, Bosnia and Herzegovina (BH), during the last decade (2015–2024). The aim is to integrate meteorological, hydrological, agricultural, and socio-economic drought signals and to delineate areas of long-term drought exposure. Meteorological drought was evaluated using CHIRPS precipitation...
Preuzmite dokument 2026 Dragutin Adžić , Davorin Bajić , Luka Sabljić , Velibor Spalevic , Dragoslav Pavić , Slobodan B. Marković , Paul Sestras , Tin Lukić
MDPI AG
Innovation for Sustainable SMEs: How Financial Health Drives Resilience and Long-Term Performance in a Transition Economy
Small- and medium-sized enterprises (SMEs) are central to sustainable development in transition economies, yet their financial fragility often limits resilience and the capacity to invest in innovation and responsible practices. Despite growing interest in SME, financial health and its role in sustainability, empirical evidence from small transition economies like Montenegro remains scarce, particularly on how liquidity and profitability dynamics underpin conditions for SDG-aligned growth. This...
Preuzmite dokument 2026 Ivana Katnic , Teodora Babic , Milorad Katnic , Vladimir Kavaric , Maja Drakic-Grgur
MDPI AG
Essential Oil of Prangos ferulacea (L.) Lindl.: Chemistry and Bioactivities
Prangos ferulacea (L.) Lindl. (Apiaceae) is an orophilous species with notable traditional uses, particularly across the broader Middle East region. Over the past 50 years, research on its essential oil has revealed the existence of several chemotypes. In addition to its chemical composition, there is also data on the biological activities of the essential oil. Among these activities, the most extensively studied are its antimicrobial and, to a lesser extent, antioxidant properties. Recent findings...
Preuzmite dokument 2026 Rino Ragno , Vanja Tadić , Milan Mladenović , Mijat Božović
MDPI AG
Phenolic Compounds, Antioxidant and Antimicrobial Activities of Punica granatum L. Fruit Extracts
Pomegranate is valued for its abundant polyphenolic content and its capacity to promote health. In this study, pomegranate juice or pericarp extracts from two Mediterranean regions (Montenegro and Italy) were systematically and comparatively evaluated for the first time with respect to their polyphenolic composition, antioxidant capacity, and antimicrobial activity. The extraction of juice extracts was accomplished by means of the Kutscher–Steudel liquid–liquid extraction technique, which was employed...
Preuzmite dokument 2026 Roberta Astolfi , Rino Ragno , Vanja Tadić , Milan Mladenović , Mijat Božović , Alessandra Oliva
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