Digital platoform

Termedia Sp. z.o.o.

Micro-ribonucleic acid modulation with oxidative stress and inflammation in patients with type 2 diabetes mellitus – a review article

In parallel with the rapid growth of obesity, there is also an increase in the prevalence of type 2 diabetes mellitus (T2D) worldwide. Due to its complications, cardiovascular diseases are the leading cause of death in those patients. In the last two decades, special attention has been given to oxidative stress and inflammation, as the underlying mechanisms related to T2D occurrence and progression. Moreover, micro-ribonucleic acids (miRNAs) as new genetic biomarkers take an important place in the...

Preuzmite dokument 2022 Jelena Kotur-Stevuljevic , Aleksandra Klisic , Irena Radoman Vujacic , Ana Ninic , Jelena Munjas

Termedia Sp. z.o.o.

Telomere-telomerase system status in patients with acute myocardial infarction with ST-segment elevation – relationship with oxidative stress

IntroductionTelomeres are protective chromosomal ends. Short telomeres are a proven biomarker of biological aging. We aimed to find an association of telomere length and telomerase activity in circulating leukocytes and thromboaspirates of patients with acute myocardial infarction. Furthermore, association of the telomere-telomerase system with oxidative stress markers (as common risk factors for coronary artery disease (CAD)) was tested.Material and methodsPatients were selected from the patients...

Preuzmite dokument 2021 Milica Stefanović , Srdjan Kafedžić , Branka Gaković , Lidija Memon , Saša Hinić , Ivan Ilić , Barbara Ostanek , Miron Sopić , Nataša Bogavac-Stanojević , Janja Marc , ... Pogledajte sve

Hindawi Limited

New Markers of Platelet Activation and Reactivity and Oxidative Stress Parameters in Patients Undergoing Coronary Artery Bypass Grafting

Objective. Recent studies have shown that the red cell distribution width- (RDW-) to-platelet (PLT) count ratio (i.e., RPR) and the mean platelet volume (MPV)/PLT ratio (i.e. MPR) are more sensitive markers of atherosclerosis-connected risk than RDW and PLT alone. The present study is aimed at investigating the oxidative stress status and these two new markers of platelet activation in two different heart surgery modalities: cardiopulmonary bypass (CPB) and off-pump coronary artery bypass (OPCAB)....

Preuzmite dokument 2021 Petar Vukicevic , Nemanja Aleksic , Vojislava Neskovic , Nataša Bogavac-Stanojević , Jelena Kotur-Stevuljevic , Aleksandra Klisic , Milos Matkovic , Luka Babic , Aleksandar Mikic , Svetozar Putnik

Hindawi Limited

Oxidative Stress in Patients before and after On-Pump and Off-Pump Coronary Artery Bypass Grafting: Relationship with Syntax Score

Objective. Coronary artery bypass grafting (CABG) represents the significant source of increased oxidative stress (OS). We aimed to follow the OS status parameters (i.e., ischemia-modified albumin (IMA), malondialdehyde (MDA), superoxide anion, prooxidant-antioxidant balance (PAB), total oxidant status (TOS), total antioxidant status (TAS), and superoxide-dismutase (SOD)) change through the predefined study times in two different surgical procedures, i.e., cardiopulmonary bypass (CPB) and off-pump...

Preuzmite dokument 2021 Petar Vukicevic , Vladimir Milićević , Nemanja Aleksic , Vojislava Neskovic , Nataša Bogavac-Stanojević , Jelena Kotur-Stevuljevic , Aleksandra Klisic , Milos Matkovic , Luka Babic , Aleksandar Mikic

Termedia Sp. z.o.o.

Natural and natural-like polyphenol compounds: in vitro antioxidant activity and potential for therapeutic application

IntroductionPhenols are a large family of natural and synthetic compounds with known antioxidant activity. The aim of this study was to preform an in vitro screening of natural and natural-like phenol monomers and their C2-symetric dimers (hydroxylated biphenyls) in order to identify those representatives which pharmacophores have the strongest antioxidant and the lowest prooxidant activity.Material and methodsAntioxidative properties of 36 compounds (monomers and their C2-symmetric dimers) were...

Preuzmite dokument 2021 Paola Carta , Giovanna Delogu , Darinka Gjorgieva Ackova , Jelena Kotur-Stevuljevic , Aleksandra Klisic , Jasmina Brboric , Maria Antonietta Dettori , Luciano Saso , Kristina Kostic , Davide Fabbri

Hindawi Limited

Factorial Analysis of the Cardiometabolic Risk Influence on Redox Status Components in Adult Population

Different byproducts of oxidative stress do not always lead to the same conclusion regarding its relationship with cardiometabolic risk, since controversial results are reported so far. The aim of the current study was to examine prooxidant determinant ((prooxidant-antioxidant balance (PAB)) and the marker of antioxidant defence capacity (total sulphydryl groups (tSHG)), as well as their ratio (PAB/tSHG) in relation to different cardiometabolic risk factors in the cohort of adult population. Additionally,...

Preuzmite dokument 2021 Sanja Vujcic , Nebojsa Kavaric , Jelena Kotur-Stevuljevic , Aleksandra Klisic , Ana Ninic , Vesna Spasojevic-Kalimanovska

Hindawi Limited

Data-Driven Cluster Analysis of Oxidative Stress Indexes in relation to Vitamin D Level, Age, and Metabolic Control in Patients with Type 2 Diabetes on Metformin Therapy

Recent advances in vitamin D research indicate that patients with type 2 diabetes mellitus (T2DM) are suffering from vitamin D deficiency and increased oxidative stress to a variable extent, which could produce different health impacts for each individual. The novel multivariate statistical method applied in the present study allows metabolic phenotyping of T2DM individuals based on vitamin D status, metabolic control, and oxidative stress status in order to identify effectively different subtypes...

Preuzmite dokument 2021 Gordana Kocic , Andrej Veljkovic , Milena M. Cojic , Aleksandra Klisic , Radivoj Kocic

Termedia Sp. z.o.o.

Serum soluble transferrin receptor levels are independently associated with homeostasis model assessment of insulin resistance in adolescent girls

IntroductionMarkers of iron homeostasis are related to insulin resistance (IR) in adults. However, studies in children and adolescents are scarce and show contradictory results. The aim was to evaluate the potential relationship between iron status markers and IR. Additionally, no previous study has explored the mutual effect of biomarkers of iron homeostasis and inflammation (i.e. high sensitivity C-reactive protein (hsCRP)), and adipokines (i.e. retinol-binding protein 4 (RBP4)) on IR in the cohort...

Preuzmite dokument 2021 Jelena Kotur , Nebojsa Kavaric , Aleksandra Klisic , Ana Ninic

Research Square Platform LLC

Oxidative Stress and Cardiometabolic Biomarkers in Patients with Non-alcoholic Fatty Liver Disease

Abstract Objective: Oxidative stress is assumed to be the underlying feature of non-alcoholic fatty liver disease (NAFLD). To our knowledge, the mutual involvement of redox status homeostasis parameters [i.e., advanced oxidation protein products (AOPP), pro-oxidant-antioxidant balance (PAB), total oxidant status (TOS), total antioxidant status (TAS) and oxidative-stress index (OSI)] and cardiometabolic biomarkers in subjects with NAFLD has not been examined yet. Accordingly, we aimed to...

Preuzmite dokument 2021 Nebojsa Kavaric , Jelena Kotur-Stevuljevic , Aleksandra Klisic , Ana Ninic

Walter de Gruyter GmbH

Ovarian female adnexal tumor of probable Wolffian origin – Case report

Abstract Background During embryonic development in women, a regression of temporary embryonic structures – mesonephric (Wolffian) ducts occurs. Adnexal tumors of Wolffian duct origin (FATWO) are rare. Case report We presented the case of a 64-year-old female patient who was diagnosed with FATWO. After the surgical treatment, the uterus with bilateral adnexal structures was submitted...

Preuzmite dokument 2021 Ljiljana Vučković , Aleksandra Klisic , Mirjana Miladinović