MDPI AG
Transcriptomic, Redox Status and Adipocytokine Profiles in Metabolic Dysfunction-Associated Steatotic Liver Disease: Impact of Coexisting Type 2 Diabetes
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) commonly coexists with type 2 diabetes (T2D), but their independent contributions to redox imbalance, inflammation and immune signaling remain uncertain. Objectives: This study aimed to evaluate whether the presence of MASLD alone, and the presence of T2D within MASLD, are independently associated with high-risk profiles of oxidative/antioxidant markers, peripheral blood mononuclear cell (PBMC) gene expression and adipocytokines....
Preuzmite dokument
2025
Sanja Erceg
,
Miron Sopić
,
Boško Misita
,
Miloš Mitrović
,
Jelena Kotur-Stevuljevic
,
Aleksandra Klisic
,
Milica Mamić
,
Ana Ninic
,
Jelena Munjas
,
Omar Ben Mariem
,
Ratko Tomašević
... Pogledajte sve
MDPI AG
Expression Analysis of Circulating miR-21, miR-34a and miR-122 and Redox Status Markers in Metabolic Dysfunction-Associated Steatotic Liver Disease Patients with and Without Type 2 Diabetes
Metabolic dysfunction-associated steatotic liver disease (MASLD), a hepatic form of metabolic syndrome, often co-occurs with type 2 diabetes (T2D) and now affects approximately 30% of the global population. MASLD encompasses conditions from simple steatosis to metabolic dysfunction-associated steatohepatitis, with oxidative stress (OS) driving progression through inflammation. This study analyzes the expression levels of circulating miRNAs and redox status markers in MASLD patients with and without...
Preuzmite dokument
2025
Sanja Erceg
,
Sanja Vujcic
,
Miron Sopić
,
Miloš Mitrović
,
Jelena Kotur-Stevuljevic
,
Aleksandra Klisic
,
Milica Mamić
,
Ana Ninic
,
Jelena Munjas
,
Ratko Tomašević
