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Interleukins: pathophysiological role in acute pancreatitis
Acute pancreatitis (AP) is a common inflammatory state characterized by a clinical course that can lead to serious local and extrapancreatic organ malfunction and failure. Interleukins (ILs) are biologically active glycoproteins primarily produced by macrophages and lymphocytes. According to the literature, there are many ILs. However, this article represents a summary of the role of ILs in AP, such as IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-11, IL-12, IL-13, IL-14, IL-15,...
Download 2024 Saima Sharif , Saira Rafaqat , Amir Hossein Behnoush , Aleksandra Klisic , Dimitrios Patoulias
MDPI AG
Interleukins: Pathogenesis in Non-Alcoholic Fatty Liver Disease
Inflammatory cytokines have been implicated as crucial contributors to the onset and progression of non-alcoholic fatty liver disease (NAFLD). The exact mechanisms by which interleukins (ILs) contribute to NAFLD may vary, and ongoing research is aimed at understanding the specific roles of different ILs in the pathogenesis of this condition. In addition, variations in environmental factors and genetics in each individual can influence the onset and/or progression of NAFLD. The lack of clinical studies...
Download 2024 Filiz Mercantepe , Sana Rafaqat , Sanja Gluscevic , Saira Rafaqat , Aleksandra Klisic
MDPI AG
The Association between Coagulation and Atrial Fibrillation
The existing literature highlights the presence of numerous coagulation factors and markers. Elevated levels of coagulation factors are associated with both existing and newly diagnosed cases of atrial fibrillation (AF). However, this article summarizes the role of coagulation in the pathogenesis of AF, which includes fibrinogen and fibrin, prothrombin, thrombomodulin, soluble urokinase plasminogen activator receptor, von Willebrand factor, P-selectin, D-dimer, plasminogen activator inhibitor-1,...
Download 2024 Saima Sharif , Sanja Gluscevic , Saira Rafaqat , Aleksandra Klisic , Dimitrios Patoulias
MDPI AG
Redox Status and Telomere–Telomerase System Biomarkers in Patients with Acute Myocardial Infarction Using a Principal Component Analysis: Is There a Link?
In the present study, we examined redox status parameters in arterial and venous blood samples, its potential to predict the prognosis of acute myocardial infarction (AMI) patients assessed through its impact on the comprehensive grading SYNTAX score, and its clinical accuracy. Potential connections between common blood biomarkers, biomarkers of redox status, leukocyte telomere length, and telomerase enzyme activity in the acute myocardial infarction burden were assessed using principal component...
Download 2023 Milica Stefanović , Srdjan Kafedžić , Aleksandar N. Nešković , Saša Hinić , Ivan Ilić , Barbara Ostanek , Miron Sopić , Nataša Bogavac-Stanojević , Janja Marc , Marija Zdravković , Jelena Kotur-Stevuljevic , Aleksandra Klisic , Aleksandra Vukašinović ... Pogledajte sve
Bentham Science Publishers Ltd.
The Link between miRNAs and PCKS9 in Atherosclerosis
Abstract: Cardiovascular disease (CDV) represents the major cause of death globally. Atherosclerosis, as the primary cause of CVD, is a chronic immune-inflammatory disorder with complex multifactorial pathophysiology encompassing oxidative stress, enhanced immune-inflammatory cascade, endothelial dysfunction, and thrombosis. An initiating event in atherosclerosis is the subendothelial accumulation of low-density lipoprotein (LDL), followed by the localization of macrophages to fatty deposits on...
Download 2023 Jasjit Suri , Esma Isenovic , Manfredi Rizzo , Mirjana Macvanin , Zoran Gluvic , Mia Manojlovic , Aleksandra Klisic
Wiley
Effect of tirzepatide on albuminuria levels and renal function in patients with type 2 diabetes mellitus: A systematic review and multilevel meta‐analysis
AbstractAimThe present systematic review aimed to summarize the available evidence from published randomized controlled trials (RCTs) regarding the effect of tirzepatide on albuminuria levels and renal function in patients with type 2 diabetes mellitus.Materials and MethodsMedline (via PubMed), Cochrane Library and Scopus were searched until 20 October 2023. Double‐independent study selection, data extraction and quality assessment were performed. Evidence was pooled with a three‐level mixed‐effects...
Download 2023 Paschalis Karakasis , Manfredi Rizzo , Nikolaos Fragakis , Aleksandra Klisic , Dimitrios Patoulias
MDPI AG
The Role of Endocan in Cardiometabolic Disorders
Discovered two decades ago, endocan still represents an intriguing biomarker related to inflammation. Endocan is a soluble dermatan sulphate proteoglycan secreted by endothelial cells. Its expression is observed in tissues related to the enhanced proliferation, especially hepatocytes, lungs, kidneys, etc. Endocan has been investigated in many cardiometabolic disorders that are tightly connected with inflammation, such as type 2 diabetes mellitus, hypertension, atherosclerotic cardiovascular disease,...
Download 2023 Aleksandra Klisic , Dimitrios Patoulias
SAGE Publications
Treatment with Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors (PCSK9i): Current Evidence for Expanding the Paradigm?
Background: Proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) are low-density lipoprotein cholesterol (LDL-C)-lowering drugs that play a critical role in lipoprotein clearance and metabolism. PCSK9i are used in patients with familial hypercholesterolemia and for the secondary prevention of acute cardiovascular events in patients with atherosclerotic cardiovascular disease (CVD). Methods: We focused on the literature from 2015, the year of approval of the PCSK9 monoclonal antibodies,...
Download 2023 Emir M. Muzurović , Manfredi Rizzo , Angelo Maria Patti , Manyoo A. Agarwal , Wael Almahmeed , Rosaria Vincenza Giglio , Aleksandra Klisic , Peter P. Toth , Marcello Ciaccio
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