Digital platoform

MDPI AG

The Potential Role of sPD-L1 as a Predictive Biomarker in EGFR-Positive Non-Small-Cell Lung Cancer

Background/Objectives: A significant breakthrough in non-small-cell lung cancer (NSCLC) treatment has occurred with the introduction of targeted therapies and immunotherapy. However, not all patients treated with these therapies would respond to treatment, and patients who respond to treatment would acquire resistance at some time point. This is why we need new biomarkers that can predict response to therapy. The aim of this study was to investigate whether soluble programmed cell death-ligand 1...

Download 2025 Ivan Soldatović , Damir Radončić , Biljana Šeha , Dragana Jovanović , Milan Savić , Natalija Samardžić , Aleksandra Klisic , Jelena Kotur Stevuljević , Milija Gajić , Marina Roksandić Milenković , ... Pogledajte sve

Walter de Gruyter GmbH

Machine learning methods for landslide mapping studies: A comparative study of SVM and RF algorithms in the Oued Aoulai watershed (Morocco)

Abstract Effective management of watershed risks and landslides necessitates comprehensive landslide susceptibility mapping. Support vector machine (SVM) and random forest (RF) machine learning models were used to map the landslide susceptibility in Morocco’s Taounate Province. Detailed landslide inventory maps were generated based on aerial pictures, field research, and geotechnical survey reports. Factor correlation analysis carefully eliminated redundant factors from the original...

Download 2025 Velibor Spalevic , Mohamed Mastere , Shuraik Kader , Latifa Ladel , Branislav Dudic

MDPI AG

New Evidence for the Contemporary Presence of Juvenile White Sharks (Carcharodon carcharias) in the Adriatic Sea

The presence of the white shark (Carcharodon carcharias) in the Mediterranean Sea is well documented, but mainly through historical and opportunistic records. Historically, the Adriatic Sea, particularly its eastern coastline, was considered a hotspot for white sharks, with relatively frequent reports of juvenile specimens suggesting a potential nursery area. However, since the second half of the 20th century, the abundance of white sharks in the Adriatic has experienced a dramatic decline, with...

Download 2025 Julia Türtscher , Jürgen Kriwet , Simone Niedermüller , Mišo Pavičić , Ilija Ćetković , Patrick L. Jambura , Pero Ugarković

Wiley

Sodium‐glucose cotransporter 2 inhibitors and outcomes in transthyretin amyloid cardiomyopathy: Systematic review and meta‐analysis

AbstractBackgroundTransthyretin amyloid cardiomyopathy (ATTR‐CM) commonly leads to heart failure but has traditionally been an exclusion criterion in randomized clinical trials (RCTs) of sodium‐glucose cotransporter 2 inhibitors (SGLT2i); therefore, the effects of these drugs in this population remain undocumented. In light of recent studies, this meta‐analysis aimed to investigate the effect of SGLT2i on the prognosis of patients with ATTR‐CM.MethodsA comprehensive search of Medline, Scopus, and...

Download 2025 Paschalis Karakasis , Panagiotis Theofilis , Manfredi Rizzo , Nikolaos Fragakis , Panayotis K Vlachakis , Aleksandra Klisic , Dimitrios Patoulias , Art Schuermans

MDPI AG

Expression Analysis of Circulating miR-21, miR-34a and miR-122 and Redox Status Markers in Metabolic Dysfunction-Associated Steatotic Liver Disease Patients with and Without Type 2 Diabetes

Metabolic dysfunction-associated steatotic liver disease (MASLD), a hepatic form of metabolic syndrome, often co-occurs with type 2 diabetes (T2D) and now affects approximately 30% of the global population. MASLD encompasses conditions from simple steatosis to metabolic dysfunction-associated steatohepatitis, with oxidative stress (OS) driving progression through inflammation. This study analyzes the expression levels of circulating miRNAs and redox status markers in MASLD patients with and without...

Download 2025 Sanja Erceg , Sanja Vujcic , Miron Sopić , Miloš Mitrović , Jelena Kotur-Stevuljevic , Aleksandra Klisic , Milica Mamić , Ana Ninic , Jelena Munjas , Ratko Tomašević

World Scientific Pub Co Pte Ltd

A condition equivalent to the Hölder continuity of harmonic functions on unbounded Lipschitz domains

Our main result concerns the behavior of bounded harmonic functions on a domain in [Formula: see text] which may be represented as a strict epigraph of a Lipschitz function on [Formula: see text]. Generally speaking, the result says that the Hölder continuity of a harmonic function on such a domain is equivalent to the uniform Hölder continuity along the straight lines determined by the vector [Formula: see text], where [Formula: see text] is the base of standard vectors in [Formula: see text]....

Download 2025 Marijan Marković

Pensoft Publishers

Water mite diversity from southwestern Türkiye through the lens of the DNA barcodes, with the description of one new species (Acari, Hydrachnidia)

This study presents the molecular and morphological results from an analysis of water mites collected in southwestern Türkiye. 83 COI barcodes are provided, clustered into 40 BINs, with 23 BINs being unique and deposited for the first time in the Barcode of Life Data Systems (BOLD). The first DNA barcodes for eight water mite species are uploaded into the BOLD database. In total, 34 water mite species were identified and one of them, Iranothyas marismortui (Gerecke, 1999) is newly reported from...

Download 2025 Milica Jovanović , İskender Gülle , Harry Smit , Vladimir Pešić , Andrzej Zawal , Pınar Gülle , Aleksandra Bańkowska , Stanisław Musielak

ASME International

Uncoupling of General Linear Multi-degree-of-freedom Structural and Mechanical Systems Through Quasi-diagonalization

Abstract This paper develops a fundamental result in linear algebra by providing the necessary and sufficient conditions for the simultaneous quasi-diagonalization of two symmetric matrices and two skew-symmetric matrices by a real orthogonal congruence. This result is used to study the uncoupling of general linear multi-degree-of-freedom (MDOF) structural and mechanical systems described by arbitrary damping and stiffness matrices through quasi-diagonalization, and real orthogonal...

Download 2025 Ranislav M. Bulatovic , Firdaus E. Udwadia

SAGE Publications

Phenolic Content and Antioxidant Potential of Wine Extracts

Background/Objective: Phenolic compounds are considered to be the most important parameters of wine quality, contributing not only to its organoleptic characteristics, but to various health benefits associated with wine consumption. Although these are successfully extracted from grapes and winemaking by-products, there is no data on extraction from wine itself. This is particularly interesting in light of the fact that the variability of wine polyphenols is not only attributed...

Download 2025 Dragana Petrović , Rino Ragno , Milan Mladenović , Mijat Božović , Danka Caković

MDPI AG

Use of Eye-Tracking Technology to Determine Differences Between Perceptual and Actual Navigational Performance

This study uses eye-tracking technology (ETT) to investigate discrepancies between seafarers’ perceived and actual performance during simulated maritime operations. The primary objective is to explore how misperceptions regarding the use of navigational tools—such as visual observation, radar, and ECDIS—may contribute to discrepancies in situational awareness, which is critical for safe navigation. By comparing participants’ self-reported perceptions with objective data recorded by ETT, the study...

Download 2025 Igor Petrović , Srđan Vujičić