The main purpose of the study was to identify the level of improvement in cognitive
flexi-bility manifested by choice and cognition reaction times in relation to manual and podal
skills as a result of the implementation of a program of therapeutic exergame exercises, for a time
interval of 6 weeks at the level of students. 511 students participated in the cross-sectional study,
of which 279 male (54.6%) and 232 female (45.4%), divided into two groups: the experimental
group 266 (521%) subjects and the control group 245 (48%) sub-jects. The implementation of the
experimental program comprising of 8 physical thera-peutic exergames took place for 6 weeks, in
one session per week, within the physical edu-cation lessons, only for the male and female
experimental groups. In the initial and final testing session, 2 standardized tests were applied:
TMT part A, B and 2 tests adapted for this study: Square Test and 25 Squares Test. The progress
registered by the male and fe-male experimental groups was statistically significant. In all tests,
the experimental groups showed higher progress compared to the control groups. Depending on
the gender differences, it was found that the male experimental and control groups made better
pro-gress compared to the female groups in the following tests: TMT part A, Square Test, 25
Squares Tests. The implementation of a physical therapeutic exergame program deter-mined the
improvement of cognitive flexibility man-ifested by choice and cognitive reac-tion times in
conditions of manual and podal motor skills, demonstrating the effective-ness of exergame
technologies adapted and implemented for prophy-lactic purposes.