21.08.2026
Termedia Sp. z.o.o.
Metabolic alterations and redox homeostasis in ferroptosis: emerging mechanisms and therapeutic implications
Ferroptosis is a programmed cell death characterized by excessive, iron-dependent accumulation of membrane lipid peroxides due to insufficient glutathione-dependent antioxidant defense. It is influenced by the metabolism of amino acids, lipids, and iron, and occurs in conditions of decreased glutathione peroxidase 4 (GPX4) activity. The increased polyunsaturated fatty acid (PUFA) content in membrane phospholipids is associated with cellular hypersusceptibility to ferroptosis. In contrast, incorporation...
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20.08.2026
MDPI AG
Regional Variations in Melanoma Histologic Characteristics: A Multicenter Cohort Study from Two Southeastern European Countries
Background/Objectives: Cutaneous melanoma prognosis is largely determined at diagnosis, with Breslow thickness, subtype and other histopathological aspects being key prognostic indicators. Variations in healthcare organization and environmental factors may influence melanoma presentation. This study aimed to compare epidemiological, clinical, and histopathological characteristics of primary cutaneous melanoma between two national referral centers in Southeastern Europe. Methods: A multicenter retrospective...
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Zoran Terzic
,
Zoran Bukumirić
,
Zorka Inić
,
Miloš Bojić
,
Marinko Paunovic
,
Marko S. Jović
,
Mileta Golubović
,
Jelena Jeremić
,
Milan Stojičić
,
Milan Jovanović
,
Branko Suđecki
Preuzmite dokument
2026
